No doubt an homage to the answer to the ultimate question of life in The Hitchhiker's Guide to the Galaxy.
The Longest Journey[]
When April first tries speaking into the Telephone Statue at the base of the Mother Tree, she says: "Hello? Testing, one...one...two...forty-two..."
Dreamfall[]
Another of Klacks' favourite pages in his biography Farewell to My Wizardin' Days.